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Research projects
Projects of the Scientific Grant Agency (VEGA)

Natural and tailored hydrophobized polysaccharides with antioxidant and associative properties
Principal investigator: Zdenka Hromádková, PhD (01/2009-12/2012)
Glycomics - its potential for rapid characterization of microorganisms
Principal investigator: Vladimír Pätoprstý, PhD (01/2009-12/2012)
Study of application of pathogen-host glycoprotein interaction in fight against the pathogen itself
Principal investigator: Jozef Nahálka, PhD (01/2010-12/2012)
Chemical preparation, characterisation and immunological properties of glycoconjugates based on selected oligosaccharide structures of antigens of pathogenic Candides
Principal investigator: Slavomír Bystrický, PhD, DSc (01/2010-12/2012)
NMR structural analysis of metabolites and other biologically active molecules
Principal investigator: Mária Matulová, PhD, DSc (01/2010-12/2012)
Microbial enzymes for bioconversion of plant hemicelluloses
Principal investigator: Peter Biely, PhD, DSc (01/2010-12/2013)
Ecology of yeasts inhabiting the fruit surfaces and flowers of fruit-trees with emphasis of their characteristics, activity, and survival
Principal investigator: Renáta Vadkertiová, PhD (01/2010-12/2013)
Deciphering the glycocode using tools of lectinomics: Nanoscale-controlled immobilisation of lectins with an microarray-based format of glycoform detection
Principal investigator: Peter Gemeiner, PhD, DSc (01/2010-12/2013)
Bioactive factor – galactoglucomannan – potential of a wood-related residue in the control of the plant development and protection
Principal investigator: Desana Lišková, PhD (01/2010-12/2013)
Study of relationship between the structure and function of the catalytic domain of alfa-mannosidases class-2
Principal investigator: Ján Mucha, PhD (01/2011-12/2013)
Characterization of signal transduction by the endoplasmic reticulum stress-responsive protein kinase endoribonuclease Ire1p
Principal investigator: Sergej Šesták, PhD (01/2011-12/2013)
Plant mucilages, structure and bioactivity
Principal investigator: Peter Capek, PhD (01/2011-12/2014)
Mimetics of glycosyltransferase inhibitors – rational design, synthesis and applications
Principal investigator: Ján Hirsch, PhD, DSc (01/2011-12/2014)
Biologically active saccharides: Synthesis, 3D structure and intermolecular interactions
Principal investigator: Miloš Hricovíni, PhD (01/2011-12/2013)
Characterization of the influenza virus neuraminidase transition states for the rational design of inhibitors
Principal investigator: Michal Raab, PhD (01/2012-12/2012)
Synthesis, structural design and evaluation of new sulfone derivatives of D-mannose – inhibitors of glycoside hydrolases
Principal investigator: Monika Poláková, PhD (01/2012-12/2014)
Novel, more efficient immobilization technologies for biocatalysts of oxo-reductive reactions and construction of biosensors and biobatteries
Principal investigator: Peter Gemeiner, PhD, DSc (01/2012-12/2015)
Investigation of molecular factors of the defense of honeybee colonies against some microbial pathogens
Principal investigator: Jaroslav Klaudiny, PhD (01/2012-12/2015)
The effect of arsenic and antimony on production and physiological characteristics of plants
Principal investigator: Desana Lišková, PhD (01/2012-12/2015)
Chemoenzymatic synthesis of key glycosynthons of natural substances
Principal investigator: Mária Mastihubová, PhD (01/2012-12/2015)
Synthesis of transition state mimetics for inhibition of glycosyltransferases
Principal investigator: Assoc. Prof. Ladislav Petruš, PhD, DSc (01/2012-12/2015)
Transglycosylases of plant and fungal cell walls
Principal investigator: Eva Stratilová, PhD (01/2012-12/2015)
NMR study of biosurfactants produced by bacteria isolated from cloud water and artic snow
Principal investigator: Mária Matulová, PhD, DSc (01/2013-12/2016)
Preparation of subcellular vaccines from oligomannoside epitopes of Candida albicans yeast and their immunomodulation properties
Principal investigator: RNDr. Eva Machová, PhD (01/2013-12/2016)
Bioactive polysaccharides from non-utilized plants and plant wastes: structural and functional diversity
Principal investigator: Ing. Zdenka Hromádková, PhD (01/2013-12/2016)
Novel technology for synthesis of sialo and a-Gal derivatives needed for development of vaccines, antibiotics and humanized plastics
Principal investigator: Ing. Jozef Nahálka, PhD (01/2013-12/2016)
Structural analysis of N-linked oligosaccharides in special diagnostics of congenital metabolic disorders of glycosylation
Principal investigator: Ján Mucha, PhD (01/2014-12/2016)
Microbial enzymes for plant hemicellulose utilization
Principal investigator: Vladimír Puchart, PhD (01/2014-12/2017)
Development of lectin, protein and glycan biochips using modern technologies and nanotechnologies for application in biology, biomedicine and for biomarkers detection
Principal investigator: Jaroslav Katrlík, PhD (01/2014-12/2017)
Study of structure and properties of biologically active saccharides using methods of NMR spectroscopy and theoretical chemistry
Principal investigator: Miloš Hricovíni, PhD (01/2014-12/2017)
Galactoglucomannan oligosaccharides signaling in plant growth processes and their protective potential against toxic metals
Principal investigator: Desana Lišková, PhD (01/2014-12/2017)
The diversity, properties and activities of soil yeasts
Principal investigator: Renáta Vadkertiová, PhD (01/2014-12/2017)
Biopolymers of microalgae, production, structural diversity and properties
Principal investigator: Peter Capek, PhD (01/2015-12/2017)
Structural design, synthesis and evaluation of selective inhibitors of glycoside hydrolases from the family 38
Principal investigator: Monika Poláková, PhD ( 01/2015-12/2018)
Investigation of honeybee larval jelly antimicrobial potential to bee brood pathogens
Principal investigator: Jaroslav Klaudiny, PhD (01/2015-12/2018)
Investigation of the stability of potential inhibitors of human glycosyltransferases
Principal investigator: Marek Baráth, PhD (01/2016-12/)
Multi-scale modelling of transition metal interactions with heterocyclic and sugar-like compounds
Principal investigator: Vladimír Sládek, PhD (01/2016-12/2019)
Structure, function and mechanism of action of plant and fungal transglycosylases
Principal investigator: Eva Stratilová, PhD (01/2016-12/2019)
Development of novel immobilized biocatalysts utilizing recombinant microorganisms for biocatalytic cascade reactions
Principal investigator: Marek Bučko, PhD (01/2016-12/2019)
Synthetic potential of marginal glycosidases
Principal investigator: Vladimír Mastihuba, PhD (01/2016-12/2018)

Projects of the Slovak Research and Development Agency (APVV)

Immobilization techniques for preparation of biocatalysts for industrial production of natural flavours
Principal investigator: Marek Bučko, PhD (05/2011-10/2014)
Systems Catalysis
Principal investigator: Igor Tvaroška, PhD, DSc (09/2010-08/2014)
Preparation of nanostructured interfaces, their integration with bioelements and subsequent use
Principal investigator: Ján Tkáč, PhD, DSc (07/2012-12/2015)
Structural design, synthesis and evaluation of selective inhibitors of glycoside hydrolases from the family 38
Principal investigator: Monika Poláková, PhD (10/2013-09/2017)
Structure, properties and biotechnological potential of novel microbial enzymes degrading plant biomass
Principal investigator: Vladimír Puchart, PhD (10/2013-09/2017)
Chemoenzymatic synthesis and evaluation of biological activities of natural glycophenolics and their analogues
Principal investigator: Mária Mastihubová, PhD (10/2013-09/2017)
Plant ionome modification by silicon for improvement of the crop nutrition quality
Project holder: Faculty of Natural Sciences CU
Principal investigator: Prof. Alexander Lux, PhD (05/2011-10/2014)
Principal investigator from IC SAS: Desana Lišková, PhD
Alteration in cell metabolism associated with drug transporter - P-glycoprotein overexpression in leukemia cells
Project holder: Institute of Molecular Physiology and Genetics SAS
Principal investigator: Zdena Sulová, PhD, DSc (05/2011-10/2014)
Principal investigator from IC SAS: Jaroslav Katrlík, PhD
Biodecorated composite magnetic nanoparticles: Preparation, collective properties and applications
Project holder: Polymer Institute SAS
Principal investigator: Prof. Ignác Capek, PhD, DSc (07/2011-12/2015)
Principal investigator from IC SAS: Peter Capek, PhD
Biotechnological preparation of new types of functional cereals and cereal products enriched with polyunsaturated fatty acids and pigments
Project holder: Faculty of Chemical and Food Technology STU
Principal investigator: Assoc. Prof. Milan Čertík, PhD (07/2011-12/2015)
Principal investigator from IC SAS: Emília Breierová, PhD
Undersdanding of plant adaptation in the radioactive Chernobyl area
Project holder: Institute of Plant Genetics and Biotechnology SAS
Principal investigator: Martin Hajduch, PhD (07/2011-12/2015)
Principal investigator from IC SAS: Jozef Nahálka, PhD
New opinions on pharmacological modulation of allergic asthma
Project holder: Commenius University, Jessenius Faculty of Medicine in Martin
Principal investigator: Assoc. Prof. Soňa Fraňová, PhD (10/2013-09/2017)
Principal investigator from IC SAS: Peter Capek, PhD
Study of regulation of radical and cellular signaling during hypertension and influence of novel therapies on this signaling
Project holder: Institute for Heart Research SAS
Principal investigator: Miroslav Barančík, PhD, DSc (10/2013-09/2017)
Principal investigator from IC SAS: Jozef Nahálka, PhD
Research and development of silicon carbide thin film technologies for applications in solar cells and thin film devices
Project holder: Institute of Electrical Engineering SAS
Principal investigator: Jozef Huran, PhD (10/2013-09/2017)
Principal investigator from IC SAS: Vlasta Sasinková, RNDr
Biochips and biosensors for glycorecognition, their development, preparation and application in cancer research
Principal investigator: Jaroslav Katrlík, PhD (07/2015-06/2019)
Possible dual function of P-glycoprotein in leukemia cells: efflux pump and regulatory protein
Project holder: Institute of Molecular Physiology and Genetics SAS
Principal investigator: Zdena Sulová, PhD, DSc (07/2015-10/2018)
Principal investigator from IC SAS: Jaroslav Katrlík, PhD
Preparation of model subcellular vaccine from mannooligomer structures of Candida albicans yeast
Principal investigator: Eva Machová, PhD (07/2016-06/2020)
Culture Collection of Yeasts as a biobank for future generations
Principal investigator: Renáta Vadkertiová, PhD (07/2016-06/2020)
Immobilized recombinant microorganisms for the biotechnological production of chemical specialties using biocatalytic cascade reactions
Principal investigator: Marek Bučko, PhD (07/2016-06/2020)
Synthetic biology for the production of new biologically active compounds in streptomycetes
Project holder: Institute of Molecular Biology SAS
Principal investigator: Ján Kormanec, PhD, DSc (07/2016-12/2019)
Principal investigator from IC SAS: Mária Matulová, PhD, DSc
Post-translation modifications in mitochondria and their role in pathological processes
Project holder: Institute of Molecular Biology SAS
Principal investigator: Eva Kutejová, PhD (07/2016-06/2020)
Principal investigator from IC SAS: Vladimír Pätoprstý, PhD
Developing new theoretical tools for prediction and interpretation of EPR and NMR parameters
Project holder: Institute of Inorganic Chemistry SAS
Principal investigator: Vladimir Malkin, PhD, DSc (07/2016-06/2020)
Principal investigator from IC SAS: Miloš Hricovíni, PhD

Projects of the FP7 EU

Electrochemical lectin and glycan biochips integrated with nanostructures (FP7-IDEAS-ERC-SG-LS9, ERC Starting Grant, FP7-311532)
Acronym: ELENA
Principal investigator: Ján Tkáč, PhD, DSc (01/2013-12/2017)
Cancer diagnosis: Parallel sensing of prostate cancer biomarkers (FP7-PEOPLE-2012-ITN)
Acronym: PROSENSE
Principal investigator: Ján Tkáč, PhD, DSc (10/2012-09/2016)
Study of reaction mechanism of glycosyl transferases using ab initio molecular dynamics as a tool for design of inhibitors (FP7/SASPRO-0005/01/02)
Acronym: SASPRO
Principal investigator: Stanislav Kozmon, PhD (07/2015-06/2018)
Integrated structural biology infrastructure for Europe (FP7/211252)
Acronym: INSTRUCT
Principal investigator: Miloš Hricovíni, PhD (04/2008-12/2015)
Microbial Resource Research Infrastructure (FP7-312251)
Acronym: MIRRI
Principal investigator: Renáta Vadkertiová, PhD (11/2012-10/2015)
Nanoparticles for therapy and diagnosis of Alzheimer disease - NAD (FP7/NMP4-LA- 2008-212043)
Acronym: NAD
Principal investigator: Igor Tvaroška, PhD, DSc (09/2008-08/2013)
Enhancing access and services to East European users towards an efficient and coordinated Pan-European pool of NMR capacities to enable global collaborative research & boost technological advancements (FP7/228461-EAST- NMR)
Acronym: EAST-NMR
Principal investigator: Miloš Hricovíni, PhD (02/2009-01/2013)

The other multilateral international projects

Mineral-improved crop production for healthy food and feed (COST Action FA0905)
Principal coordinator: Prof. Bal Ram Singh (Norway, 01/2010-04/2014)
Principal investigator from IC SAS: Desana Lišková, PhD
Colloidal aspects of nanoscience for innovative processes and materials (COST CMST Action CM1101)
Principal coordinator: Prof. Piotr Warszynski (Poland, 06/2011-01/2016)
Principal investigator from IC SAS: Peter Gemeiner, PhD, DSc
Multivalent glycosystems for nanoscience - MultiGlycoNano (COST CMST Action CM1102)
Principal coordinator: Dr. Bruce Turnbull (Great Britain, 11/2011-11/2015)
Principal investigator from IC SAS: Igor Tvaroška, PhD, DSc
Food waste valorisation for sustainable chemicals, materials & fuels (EUBis) (FA COST Action TD1203)
Principal coordinator: Prof. James Clark (Great Britain, 11/2012-11/2016)
Principal investigator from IC SAS: Zdenka Hromádková, PhD
Chemical approaches to targeting drug resistance in cancer stem cells (COST CMST Action CM1106)
Principal coordinator: Prof. Daniele Passarella (Italy, 03/2012-03/2016)
Principal investigator from IC SAS: Igor Tvaroška, PhD, DSc
Systems biocatalysis (CMST COST Action CM1303)
Principal coordinator: Prof. Stefano Servi (Italy, 11/2013-11/2017)
Principal investigator from IC SAS: Jozef Nahálka, PhD
Valorisation of lignocellulosic biomass side streams for sustainable production of chemicals, materials & fuels using low environmental impact technologies (FPS COST Action FP1306)
Principal coordinator: Dr. Rafael Luque (Spain, 05/2014-05/2018)
Principal investigator from IC SAS: Vladimír Mastihuba, PhD
ESF-EuroGlycoforum-Research Networking Program (ESF-Research Networking Programmes-LESC, 07-RNP-015)
Acronym: Euroglycoscience
Principal coordinator: Prof. Sabine L. Flitsch (Great Britain, 05/2009-04/2014)
Principal investigator from IC SAS: Ján Mucha, PhD
Multidisciplinary frontiers of magnetic resonance (ESF/RNP-PESC-05-PGM-022)
Acronym: EMAR
Principal investigator: Prof. Miquel Pons (Spain, 04/2007-04/2012)
Principal investigator from IC SAS: Mária Matulová, PhD, DSc
Analytical techniques for biorefinerie (FPS COST Action FP0901)
Principal investigator: Prof. Stefan Willför (Finland, 08/2009-05/2013)
Principal investigator from IC SAS: Zdenka Hromádková, PhD
Cascade chemoenzymatic processes - new synergies between chemistry and biochemistry (CMST COST Action CM0701)
Principal investigator: Dr. Sergio Riva (Italy, 10/2008- 04/2012)
Principal investigator from IC SAS: Peter Gemeiner, PhD, DSc
Challenging organic syntheses inspired by nature – from natural products chemistry to drug discovery (CMST COST Action CM1407)
Principal investigator: Prof. Bruno Botta (Italy, 03/2015-03/2019)
Principal investigator from IC SAS: Mária Mastihubová, PhD

Institute of Chemistry
Slovak Academy of Sciences
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2016