About the Institute of Chemistry, SAS People at the Institute of Chemistry, SAS Research groups at the Institute of Chemistry, SAS Research at the Institute of Chemistry, SAS Products of the Institute of Chemistry, SAS






Education
  • Study on biosynthesis of capsular polysaccharides of yeasts Cryptococcus laurentii.

  • Regulation of capsule formation in the yeast Cryptococcus.

  • New flow biosensor systems with amperometric and calorimetric detection for fermentation and biotransformation monitoring.

  • Synthesis of glycofuranosyl and glycopyranosyl C-nucleosides and their analogs.
  • PhD student: Michal Vojtech, MSc

  • Preparation and immunological properties of mannan-protein conjugates of potential pathogenic Candida and Malassezia species.
  • Supervisor: Eva Machová, PhD

  • Microbial esterases of wooddestroying fungi Phanerochaete chrysosporium.

  • Study of structure-function relation of model organism of alpha 1,3 core fucosyltransferase.
  • PhD student: Peter Both, MSc
    Supervisor: Ján Mucha, PhD

  • Isolation and characterization of plant transglycosylases.

  • Preparation and structural characterization of bioactive and other functional polysaccharides from economically important agricultural plants.

  • Biological activity of the cell wall polysaccharides of yeasts and filamentous fungi.

  • GlycoGold: Exploration of the nature and potential of glyco-nano-particles.

  • Novel assay methods for transglycosylases.
  • PhD student: Ondřej Kosík, MSc

  • Molecular modeling of catalytic mechanism of glycosyltransferases and design of their inhibitors.
  • PhD student: Michal Raab, MSc

  • Molecular modeling of the transition state structure of catalytic reactions.

  • Immumological characterization of dominant mannoprotein antigens of Candida sp., use for the preparation of subcellular vaccines.

  • Newly emerging phatogens - vibrios. Study of virulence and possible immunomodulative prevention.

  • Study of the yeast Cryptococcus laurentii capsule biosynthesis.

  • Production of antimicrobial peptides in honeybee colonies.

  • NMR study of metabolism of bacteria isolated from clouds water: their role in chemistry of the atmosphere.
  • Supervisor: Anne Marie Delort, PhD (University Blaise Pascal, Clermont Ferrand, France)

  • Study of immunity responce induced by surface saccharides of microbial pathogens.

  • Enzymatic acylations of saccharides under non-conventional conditions.

  • Chemoenzymatic preparation of biospecific oligosaccharides.


  • 2008
  • Immobilized biosystems: Potential and limitations of encapsulation of biocatalysts in polymer microcapsules.
  • PhD student: Marek Bučko, PhD

  • The role of transglutaminase in biosynthesis fungal cell walls.

  • Synthesis and characterization of neoglycoconjugates based on LPS of Vibrio cholerae 01.

  • Hyaluronic acid derivatives with biological properties.

  • 2007
  • Regulation of xylogenesis in vitro - effect of GGMOs on tracheary elements differentiation.

  • Microbial esterases of wooddestroying fungi Schizophylum commune.

  • The influence of chemical and physical factors on the yeast microflora in winery large production.

  • Reaction mechanism of glycosyltransferases.

  • Identification and some aspects of expression of larval nutrition antimicrobial peptide - royalisine in various colonies of honeybees Apis mellifera L.

  • Utilization of MALDI and ESI-MS techniques in the study of biomolecules.

  • 2006
  • Preparation, chemical and immunological characterization of glycoconjugates based on polysaccharidic surface antigens from the yeasts of Candida genus as potential vaccines.

  • Conidiation of Trichoderma fungi and its utilization in the culture plants protection.

  • Preparation of mimetics of lipide A.

  • Assay methods and isolation of xyloglucan endotransglycosylase (XET) isoforms from nasturtium (Tropaeolum majus) seeds.

  • 2005
  • Xylanolytic system of Schizophyllum communae.

  • Synthesis of anhydronitroalditol-based C-glycosylating agents.

  • Synthesis and characterization of aminoderivatives of saccharides structurally related to mannojirimycin.

  • Use of lignin in polymer blends.

  • 2003
  • Mechanism of reaction catalyzed by xyloglucan endotransglycosylase (XET).

  • Biophysical study of hyaluronan structure and pahtological processes in cartilage and brain using nuclear magnetic resonance.

  • Mrjp gene family of honeybee (Apis mellifera L.): computer analysis of putative mrjp promoters and genomic structure of mrjp1 gene coding for the most abundant protein of royal jelly.

  • Synthesis of bioactive proteins of larval nutrition of honey bees by heterologous expression.

  • 2002
  • Synthesis of glycoproteins. Preparation, characterization and their interaction with concanavalin A.

  • Isolation, characterization and function of lectin from Pinus nigra ARN.

  • Isolation and characterization of biologically active proteins and antimicrobial peptides of honeybee royal jelly.

  • 2001
  • Synthesis and properties of model compounds for ester type of lignin-carbohydrate linkage.
  • Supervisor: Dušan Joniak, PhD

  • Photoinduced conidiation in the fungus Trichoderma viride.

  • Plant β-mannans and their enzymatic degradation.

  • Biosynthesis of galactosylated glycoproteins in the yeast Cryptococcus laurentii.

  • 1999
  • Annulated derivatives of purine-2,6-diones.
  • Supervisor: Alfonz Rybár, PhD

  • Synthesis of C-glycosyl analogues of biologically significant saccharides.

  • Biotechnological use of plant cell biomass for production of secondary metabolites.

  • Mutual isomerization of 2-ketoses and 2-C-(hydroxymethyl)aldoses catalyzed by molybdic acid.

  • Isolation and biochemical characterization of a GTP-ase-activating protein specific for members of Ypt/Rab family of small GTP-ases.

  • 1998
  • Chemical ionization mass spectrometry of saccharides.

  • Characterization of immobilized biocatalysts using flow microcalorimetry.

  • β-Mannanolytic system of Aureobasidium pullulans.

  • Institute of Chemistry
    Slovak Academy of Sciences
    webmaster@chem.sk
    2010