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Slavomír BYSTRICKÝ, PhD, DSc
Senior Research Scientist

Tel.: +421-2-59410221
Fax.: +421-2-59410222


Immunology, chemistry and stereochemistry of carbohydrates.


Chemical conjugation of biomacromolecules: A mini-review.
Farkas, P., Bystricky, S.
Chemical Papers 64, 683-695, 2010
Synthesis of 3,6-branched oligomannoside fragments of the mannan from Candida albicans cell wall corresponding to the antigenic factor 4.
Karelin, A.A., Tsvetkov, Y.E., Paulovičová, L.,et al.
Carbohyd Res. 345, SI, 1283-1290, 2010
Model alpha-mannoside conjugates: immunogenicity and induction of candidacidal activity.
Paulovicova, L., Bystricky, S., Paulovicova, E., et al.
Fems Immunology and Medical Microbiology 58, 307-313, 2010
Preparation of synthetic polyoxazoline based carrier and Vibrio cholerae O-specific polysaccharide conjugate vaccine.
Farkas, P., Korcova, J.,Kronek, J., et al.
European Journal of Medicinal Chemistry 45, 795-799, 2010
Vibrio cholerae O1 Ogawa detoxified lipopolysaccharide structures as inducers of cytokines and oxidative species in macrophages.
Paulovicova, E., Kovacova, E., Bystricky, S.
Journal of Medical Microbiology 59, 158-164, 2010
Synthesis of a heptasaccharide fragment of the mannan from Candida guilliermondii cell wall and its conjugate with BSA.
Karelin, A.A., Tsvetkov, Y.E., Paulovicova, L., et al.
Carbohydrate Research 344, 29-35, 2009
Growth Inhibition of Candida albicans in the Presence of Antiserum Elicited in Rabbits by Mannan-Protein Conjugate.
Machova, E., Bystricky, S.
Zeitschrift fur Naturforschung Section c-a Journal of Biosciences 63, 909-912, 2008
Immune responsiveness of a novel peptidoglycan conjugate prepared from surface Candida immunogens: mannan and CR3-related protein.
Paulovicova, E., Bystricky, S., Machova, E., et al.
Fems Immunology and Medical Microbiology 53, 421-428, 2008
Hydrolysis of the terminal dimethylacetal moiety on the spacers bound to carboxy groups containing glucans.
Farkas, P., Bystricky, S.
Carbohydrate Polymers 74, 133-136, 2008
Activation of mouse peritoneal macrophage by LPS derived immunogens.
Paulovicova, E., Kovacova, E., Bystricky, S.
Allergy 63, 410-410, 2008
Evaluation of different mannan polysaccharide usage in enzyme-linked immunosorbent assay for specific antibodies determination.
Libjakova, L., Bystricky, S., Lizicarova, I., et al.
Journal of Pharmaceutical and Biomedical Analysis 45, 521-525, 2007
Cell and antibody mediated immunity induced by vaccination with novel Candida dubliniensis mannan immunogenic conjugate.
Paulovicova, E., Machova, E., Tulinska, J., et al.
International Immunopharmacology 7, 1325-1333, 2007
Preparation and characterization of biodegradable alkylether derivatives of hyaluronan.
Mlochova, P., Hajkova, V., Steiner, B., et al.
Carbohydrate Polymers 69, 344-352, 2007
Efficient activation of carboxyl polysaccharides for the preparation of conjugates.
Farkas, P., Bystricky, S.
Carbohydrate Polymers 68, 187-190, 2007
Synthesis of oligosaccharide fragments of mannan from Candida albicans cell wall and their BSA conjugates.
Karelin, A.A., Tsvetkov, Y.E., Kogan, G., et al.
Russian Journal of Bioorganic Chemistry 33, 110-121, 2007
Immunological properties of complex conjugates based on Vibrio cholerae O1 Ogawa lipopolysaccharide antigen.
Paulovicova, E., Machova, E., Hostacka, A., et al.
Clinical and Experimental Immunology 144, 521-527, 2006
Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives.
Mlcochova, P., Bystricky, S., Steiner, B., et al.
Biopolymers 82, 74-79, 2006
Functionalization of mannans from pathogenic yeasts by different means of oxidations - preparation of precursors for conjugation reactions with respect to preservation of immunological properties.
Durana, R., Lacik, I., Paulovicova, E., et al.
Carbohydrate Polymers 63, 72-81, 2006
Immune response to Saccharomyces cerevisiae mannan conjugate in mice.
Paulovicova, E., Bystricky, S., Masarova, J., et al.
International Immunopharmacology 5, 1693-1698, 2005
Synthesis and immunogenicity of polysaccharide-protein conjugate composed of galactoglucoxylomannan of Cryptococcus laurentii.
Bystricky, S., Paulovicova, E., Machova, E.
Fems Microbiology Letters 235, 311-314, 2004
Synthesis of a precursor of a lipid a mimic.
Barath, M., Petrusova, M., Bystricky, S., et al.
Chemical Papers-Chemicke Zvesti 57, 125-130, 2003
Physical, chemical, antigenic, and immunologic characterization of polygalacturonan, its derivatives, and Vi antigen from Salmonella typhi.
Szu, S.S.C., Bystricky, S.
Recognition of Carbohydrates in Biological Systems, part b: specific applications 363, 552-567, 2003
Candida albicans mannan-protein conjugate as vaccine candidate.
Bystricky, S., Paulovicova, E., Machova, E.
Immunology Letters 85, 251-255, 2003
Preparation and characterization of adipic acid dihydrazide derivatives of yeast mannans. Durana, R., Bystricky, S.
Carbohydrate Polymers 50, 177-181, 2002
Preparation of a subcellular conjugate with the lipopolysaccharide from Vibrio cholerae 01 using beta-D-glucan as matrix.
Machova, E., Bystricky, S., Galikova, A., et al.
European Journal of Medicinal Chemistry 37, 681-687, 2002
Nonbiodegradable hyaluronan derivative prepared by reaction with a water-soluble carbodiimide.
Bystricky, S.,Alfoldi, J., Machova, E., et al.
Chemical Papers-Chemicke Zvesti 55, 49-52, 2001
Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) - an effective route of antifungal vaccine preparation.
Bystricky, S., Machova, E., Bartek, P., et al.
Glycoconjugate Journal 17, 677-680, 2000
Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) - effective route of antifungal vaccine preparation.
Bystricky, S., Machová, E., Bartek, P., Kolarova, N., Kogan, G.
Glycoconjugate J. 17, 677-680, 2000.
Nonbiodegradable hyaluronan derivative prepared by reaction with a water-soluble carbodiimide.
Bystricky, S. Alfoldi, J., Machová, E., Steiner, B., and ©oltés L.
Chem. Pap. 55, 49-52, 2001.
Determination of cross-linking effect of adipic acid dihydrazide at glycoconjugate preparation.
Bystrický, S., Machová, E.,Malovíková A and Kogan G.
Glycoconj. J. 16, 691-695, 1999.
Treatment with succinic anhydrate improves the immunogenicity of Shigella flexneri type 2a O-specific polysaccharide-protein conjugates in mice.
Pavliakova, D., Chu, Ch., Bystrický, S., Tolson, N., Shiloach, J., Kauffman J.B., Bryla, D., Robbins, J.B., and Schneerson, R.
Infect. Immun. 67, 5526-5529, 1999.
Cyclodextrin derivative of hyaluronan.
©oltés, L., Mendichi, R., Machová, E., Steiner, B., Alfoldi, J., Sasinková, V., Bystrický, S., and Balog, K.
Carb. Polymers 39, 17-24, 1999.
Conformational differences among mono- and oligosaccharide fragments of the O-specific polysaccharides of Vibrio cholerae O:1 revealed by circular dichroism.
Bystricky, S., Szu, S.C., Zhang,J., and Kovac,P.
Carb. Research 314, 135-139, 1998.
On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, Ogawa and Inaba.
Wang, J., Villeneuve, S., Zhang, J., Lei, P.-S., Miller, C.E., Lafaye, P., Nato, F., Szu, S.C., Karpas, A., Bystricky, S., Robbins, J.B., Kovac, P., Fournier, J.M., and Glaudemans, C.P.J.
J. Biol. Chem. 273, 2777-2783, 1998.
Synthesis and immmunological properties of Vi and di-o-acetyl pectin conjugates with adipic acid dihydrazide as the linker.
Kossaczka, Z., Bystricky, S., Bryla, D.A., Shiloach, J., Robbins, J.B., and Szu, S.C.
Infect. Immun. 65, 2088-2093, 1997.
Characterization of colominic acid by circular dichroism and viscosity analysis.
Bystricky, S., Pavliak, V., and Szu, S.C.
Biophys. Chem. 63, 147-152, 1997.
Conformational analysis and molecular dynamics simulation of a &-(1→2) and &-(1→3) linked rhamnose oligosaccharides: Reconciliation with optical rotation and NMR experiments.
Hardy, B.J., Bystricky, S., Kovac, P., and Widmalm, G.
Biopolymers 41, 83-96, 1997.
Flexibility and circular dichroism characteristic of poly a-(2-8) sialic acids.
Bystricky, S. and Szu, S.,C.
Biophysic. J. 68, A409, 1995.
Characterization of a human monoclonal immunoglobulin M (IgM) antibody (IgMBEN) specific for Vi capsular polysaccharide of Salmonella typhi.
Liao, J., Nickerson, K.G., Bystricky, S., Robbins, J.B., Schneerson, R., Szu, S.C., and Kabat, E.A.
Infect. Immun. 63, 4429-4432, 1995.
Circular dichroism of the O-specific polysaccharide of Vibrio cholerae O1 and some related derivates.
Bystricky, S., Szu, S.C., Gotoh, M., and Kovac, P.
Carbohydr. Res. 270, 115-122, 1995.
Synthesis and some immunologic properties of an O-acetyl pectin [poly(1-4) &-D-GalpA]-protein conjugate as a vaccine for typhoid fever.
Szu, S.C., Bystricky, S., Hinojosa-Ahumada, M., Egan, W., and Robbins, J.B.
Infect. Immun. 62, 5545-5549, 1994.
O-Acetylation affects the binding properties of the carboxyl groups on the Vi bacterial polysaccharide.
Bystricky, S., and Szu, S.C.
Biophys. Chem. 51, 1-7, 1994.
Solution conformation of methyl β-xylobioside.
Stevens, E.S., Bystricky, S., and Hirsch, J.
Carbohydr. Res. 239, 1, 1993.
Interaction of pectin with cationic polypeptides.
Bystricky, S., and Malovikova, A.
Chem. Papers 46, 131, 1992.
Interaction of pirprofen enantiomers with human serum albumin.
Oravcova, J., Mlynárik, V., Bystrický, S., ©oltés, L., Szalay, P., Bohá`eik, L., and Trnovec, T.
Chirality 3, 412-417, 1991.
Interaction of acidic polysaccharides with polylysine enantiomers. Conformation probe in solution.
Bystricky, S., Malovikova, A., and Sticzay, T.
Carbohydr. Polym. 15, 299, 1991.
Conformations of (1→4)-linded &-D-galacturono-di- and tri-saccharides in solution analyzed by n.m.r. measurements and theoretical calculations.
Hricovini, M., Bystricky, S., and Malovikova, A.
Carbohydr. Res. 220, 23, 1991.
Interactions of alginates and pectins with cationic polypeptides.
Bystricky, S., Malovikova, A., and Sticzay, T.
Carbohydr. Polym. 13, 283, 1990.
Structure of 7,14,15,17-tetraoxa-10-azapentacyclo[10.2.1.12,11.15,8.03,9]-heptadeca-3,9-dien-2-OL, a pentacyclic alcohol prepared from levoglucosenone.
Kettmann, V., Bystricky, S., Sticzay, T., and Koos, M.
Acta Crystallogr. C 45, 1580-1583, 1989.
Different binding of propanolol enantiomers to human alpha 1 - acid glycoprotein.
Oravcova, J., Bystricky, S., and Trnovec, T.
Biochem. Pharmacol. 38, 2575, 1989.
An activation of effect of some phenolics on enzymatic hydrolysis of polysaccharides.
Pekarovicova, A., Luzakova, V., Bystricky, S., Pekarovic, J., and Kosik, M.
Cellulose Chem. Technol. 23,225, 1989.
Complexation of poly(Lys-Ala-Ala) with pectins and potassium oligogalacturonates.
Bystricky, S., Malovikova, A., Sticzay, T., and Blaha, K.
Collect. Czech. Chem. Commun. 53, 2833, 1988.
Rapid optical resolution of anionic metal complexes by gel permetation chromatography.
Strasak, M., and Bystricky, S.
J. Chromatogr. 450, 284, 1988.
Partial resolution of Co(III) chelate complexes by gel permetation chromatography.
Strasak, M., and Bystricky, S.
J. Chromatogr. 403, 331, 1987.
Structural and chiroptical properties of rigid system with planar a,b-unsaturated imine group.
Bystricky, S., Sticzay, T., Koos, M., and Kettmann, V.
Chem. Papers 40, 79, 1986.
Formation of the poly(Lys-Ala-Ala) complex with potassium oligogalacturonates.
Bystricky, S., Sticzay, T., Kohn, R., and Blaha, K.
Collect. Czech. Chem. Commun. 51, 2919, 1986.
Formation of the poly(Lys-Ala-Ala) complex with pectin of various esterification degree.
Bystricky, S., Kohn, R., Sticzay, T., and Blaha, K.
Collect. Czech. Chem. Commun. 51, 1772, 1986.
Spectrophotomeric study of guanyloribonuclease Sa III circular dichroism spectra.
Kery, V., Zelinka, J., and Bystricky, S.
Biologia 41, 349, 1986.
Circular dichroism of the guanosine 3'-phosphate.
Kery, V., Bystricky, S., Sevcik, J., and Zelinka, J.
Biochim. Biophys. Acta 869, 75, 1986.
Formation of the poly(L-lysine) complex with pectin of various esterification degree.
Bystricky, S., Kohn, R., Sticzay, T., and Blaha, K.
Collect. Czech. Chem. Commun. 50, 1097, 1985.
The stereochemistry of mixed ligand Co III complexes of amino acid derivatives.
Strasak, M., Novomesky, P., and Bystricky, S.
Proc. Coord. Chem. 10, 383, 1985.
Chiroptical properties of monosaccharide acetyl derivatives.
Bystricky, S., Sticzay, T., Kucar, S., Petrakova, E., and Toman, R.
Collect. Czech. Chem. Commun. 50, 683, 1985.
Chiroptical and conformational properties of ketohexoses.
Bystricky, S., Sticzay, T., and Kucar, S.
Collect. Czech. Chem. Commun. 49, 828, 1983.
Chiroptical properties of D-galactosyl derivatives of nitromethane.
Bystricky, S., Sticzay, T. and Petrus, L.
Chemicke Zvesti 36, 832, 1982.
Preparation of some glycosyl derivatives of nitromethane.
Petrus, L., Bystricky, S., Sticzay, T., and Bilik, V.
Chemicke Zvesti 36, 103, 1982.
Non-planar conformations of N-methylacetamide: Solvent effect and chiroptical properties.
Tvaroska, I., Bystricky, S., Malon, P., and Blaha, K.
Collect. Czechoslov. Chem. Commun. 47, 17, 1982.
Theoretical calculation of optical activity of the nonplanar a,b-unsaturated imines.
Bystricky, S., Koos, M., and Repas, M.
Chemicke Zvesti 35, 679, 1981.
Study of D-glyceraldehyde by circular dichroism and ultraviolet spectroscopy.
Bystricky, S., Sticzay, T., Polakova, M., and Fedoronko, M.
Collect. Czechoslov Chem. Commun. 46, 240, 1981.
Studies on CD. Aldooligouronic acid derivatives.
Sticzay, T., Bystricky, S., Hirsch, J., and Kovac, P.
Chemicke Zvesti 34, 793, 1980.
Effect of temperature of chiroptical and conformational properties of acyclic ketoses.
Bystricky, S., Sticzay, T., and Tvaroska, I.
Collect. Czechoslov. Chem. Commun. 45, 475, 1980.
Conformation of 3-acetamido-3,6-dideoxyhexopyranosides. Circular dichroism study.
Bystricky, S., Fric, I., Stanek, J., Capek, K., Jary, J., and Blaha, K.
Collect. Czechoslov. Chem. Commun. 44, 174, 1979.
Effect of polymerization degree of oligogalacturonates and D-galacturonans on their circular dichroic spectra.
Bystricky, S., Kohn, R. and Sticzay, T.
Collect. Czechoslov. Chem. Commun. 44, 167, 1979.
Semiempirical calculation of optical rotatory strength of non-planar conformation of formamide.
Malon, P., Bystricky, S., and Blaha, K.
Collect. Czechoslov. Chem. Commun. 43, 781, 1978.
Chiroptical properties of L-altruronic acid.
Bystricky, S., Sticzay, T., and Kovac, P.
Collect. Czechoslov. Chem. Commun. 43, 2062, 1978.
Chiroptical properties of esters of some uronic acids.
Sticzay, T., Bystricky, S., Peciar, C., and Hirsch, J.
Collect. Czechoslov. Chem. Commun. 43, 1496, 1978.
Conformational analysis of 2-acetamido-1,3-propanendiol as a model of 3-acetamido-3-deoxyhexopyranoses.
Bystricky, S., Tvaroska, I., and Blaha, K.
Collect. Czechoslov. Chem. Commun. 42, 1002, 1977.
Chiroptical properties of some acyclic ketoses.
Sticzay, T., Bystricky, S., Peciar, C., Linek, K., and Stankovic, L.
Chemicke Zvesti 30, 703, 1976.
Purdie reagent inducet C(5) - epimerization of D-galacturonic acid derivatives in the presence of methyl sulphide.
Kovac, P., Hirsch, J., Palovcik, R., Tvaroska, I., and Bystricky, S.
Collect. Czechoslov. Chem. Commun. 41, 3119, 1976.
Conformation and chiroptical properties of g-lactones of aldonic acids.
Bystricky, S., Sticzay, T., Kucar, S., and Peciar, C.
Collect. Czechoslov. Chem. Commun. 41, 2749, 1976.
Chiroptical properties of some flavone and isoflavone glycosides.
Sticzay, T., Bystricky, S. Peciar, C., Levai, A., and Bognar, R.
Chemicke Zvesti 29, 538, 1975.
Biological and chiroptical sequelae of graded alkyl substitutions of the vasopressin ring.
Cort, J.H., Fric, J., Carlsson, L., Gillessen, D., Bystricky, S., Skopkova, J., Gut, V., Studer, R.O., Mulder, J.L., and Blaha, K.
Mol. Pharmacol. 12, 313, 1976.
The problem of carotenoid biosynthesis in the taxonomy of genera Rhodotorula and Rhodosporidium.
Kockova-Kratochvilova, A., and Bystricky, S.
Mycopat. Mycologia Applicata 54, 409, 1974.
2,3-unsaturated esters of aldonic acids.
Sticzay, T., Peciar, C., Bystricky, S., and Kucar, S.
Chemicke Zvesti 28, 226, 1974.
Chiroptical differentiation of isoflavone glycosides.
Levai, A., Bognar, R., Peciar, C., Bystricky, S., and Sticzay, T.
Acta Chim. (Budapest) 79, 365, 1973.
Chapters in books
Optické metódy.
Bystricky, S.
In Biochemické Laboratórne Metódy (eds.Feren`eík,M., ©karka, B.), SNTL, Bratislava, 1981
Conformation Presumption for Polysaccharide-Polylysine Complexation.
Bystricky, S. and and Malovíková, A.
in Macromolecular Complexes in Chemistry and Biology (eds. Dubin, P., Bock, J., Davis, R., Schulz, D.N. and Thies, C.) Springer-Verlag, Berlin, 1994.


Method of preparation of ultra-high molecular weight hyaluronans by physico-chemical crosslinking of derivatives of high molecular weight hyaluronic acid or of its salts.
L. ©oltés, S. Bystrický, B. Steiner, E. Machová, R. Mendichi, V. Bauer, G. Kogan, J. Alföldi, E. Stratilová, M. Mach
Slovak Patent No. 282717 (12.9.2002)

Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals.
L. ©oltés, B. Steiner, E. Machová, G. Kogan, S. Bystrický, R. Mendichi
International Patent C08B 37/08, International Publication Number WO 01/66601 A1 (13 September 2001).

Synthesis of Typhoid Fewer Vaccine from a Plant or Fruit Polysaccharide
Shu, S.C. and Bystrický, S.
U.S. Patent 5,738,855.

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Slovak Academy of Sciences
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