About the Institute of Chemistry, SAS People at the Institute of Chemistry, SAS Research groups at the Institute of Chemistry, SAS Research at the Institute of Chemistry, SAS Products of the Institute of Chemistry, SAS






Miroslav KOÓ©, PhD, DSc
Senior Research Scientist
Director

Laboratory of Glycoconjugates

Tel.: +421-2-59410254
Fax: +421-2-59410222
Research Interests
Synthesis and structural studies of mono- and oligosaccharide derivatives and glycoconjugates (especially amino- and iminosugars and sugar amino acids - potential glycosidase inhibitors), five- and six-membered heterocyclic compounds (especially pyrazoles, imidazoles, oxazolidines, 1,3-dioxolanes, thiazoles, pyrimidines) and hyaluronan derivatives.
Selected Publications (full list available on request)
Koó¹ M., Repá¹ M., Èiha M., Koèi¹ P.
Identification of 3-hydroxy-6-methyl-2H-pyran-2-one from pyrolysis of phosphoric acid-treated cellulosic materials.
Carbohydr. Res. 1980, 80, 333-335.
Koó¹ M., Steiner B., Repá¹ M., Sasinková V.
Preparation and characterization of some 2,5- and 2,3,5-substituted oxazolidines.
Chem. Papers 1984, 38, 699-706.
Koó¹ M., Mosher H. S.
Isopropylidenation of L-Arabinose N,N-Dimethylhydrazone.
Collect. Czech. Chem. Commun. 1985, 50, 1994-1999.
Koó¹ M., Mosher H. S.
A convenient synthesis of apiose.
Carbohydr. Res. 1986, 146, 335-341.
Kettmann V., Bystrický S., Sticzay T., Koó¹ M.
Structure of 7,14,15,17-Tetraoxa-10-azapentacyclo[10.2.1.12,11.15,8.03,9]heptadeca-3,9-dien-2-ol, a Pentacyclic Alcohol Prepared from Levoglucosenone.
Acta Crystallogr. 1989, C45, 1580-1583.
Koó¹ M., Repá¹ M., Steiner B., Mlynarèík D.
Preparation, characterization, and antimicrobial properties of some 1,3,5-substituted 2-pyrazolines.
Chem. Papers 1990, 44, 105-110.
Koó¹ M., Steiner B., Repá¹ M.
Influence of structure on antimicrobial activity of some heterocycles. I. Alkylpyrazoles and alkylisoxazoles.
Chem. Papers 1991, 45, 279-286.
Steiner B., Koó¹ M., Matulová M., Proksa B.
Synthesis of 2-Acetyl-3-methyl-4H-1,4-benzothiazine and its Derivatives.
Monatsh. Chem. 1993, 124, 425-430.
Koó¹ M., Mosher H. S.
α-Amino-α-trifluoromethyl-phenylacetonitrile: A Potential Reagent for 19F NMR Determination of Enantiomeric Purity of Acids.
Tetrahedron 1993, 49, 1541-1546.
Koó¹ M., Steiner B., Novotná Z.
Influence of Structure on Antimicrobial Activity of Some Heterocycles.
IV. 1-(3-Alkylamino-2-hydroxypropyl)-2-methyl-5-nitroimidazoles.
Chem. Papers 1994, 48, 54-57.
Koó¹ M.
Synthesis and Antimicrobial Activity of Some 2-Alkyl-2H-1,4-benzothiazin-3(4H)-ones and 2-Alkylbenzo[d]imidazolo[2,1-b]thiazolidin-3-ones.
Monatsh. Chem. 1994, 125, 1011-1016.
Köll P., Saak W., Pohl S., Steiner B., Koó¹ M.
Preparation and crystal and molecular structure of 6-O-[(2S)-2,3-epoxypropyl]-1,2:3,4-di-O- isopropylidene-galactopyranose. Pyranoid ring conformation in 1,2:3,4-di-O-isopropylidene- galactopyranose and related systems.
Carbohydr. Res. 1994, 265, 237-248.
Koó¹ M.
A Versatile Route to 2,3-Unsaturated Sugar Derivatives via Corresponding 3-Acetoxy-1-Nitro-1-Alkenes.
Tetrahedron Lett. 1996, 37, 415-416.
Sasinková V., Koó¹ M.
An Alternative Synthesis of Nojirimycin and Idonojirimycin.
Chem. Papers 1997, 51, 147-152.
Hirsch J., Koó¹ M., Kováè P.
Improved synthesis of an aldobiouronic acid related to hardwood xylans, and preparation of a derivative thereof suitable for linking to proteins.
Carbohydr. Res. 1998, 310, 145-149.
Steiner B., Koó¹ M., Langer V., Gyepesová D., Smrèok ¥.
4-Amino-4-cyano-4,6-dideoxy sugar derivatives from methyl 6-deoxy-2,3-O-isopropylidene- α-L-lyxo-hexopyranosid-4-ulose via Strecker-type reaction.
Carbohydr. Res. 1998, 311, 1-9.
Koó¹ M., Steiner B., Gajdo¹ J., Langer V., Gyepesová D., Smrèok ¥., Ïurík M.
Crystal Structure of Methyl 4-acetamido-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-ß-D-allopyranoside.
Molecules 2000, 5, 219-226.
Koó¹ M., Steiner B., Langer V., Gyepesová D., Ïurík M.
Preparation and structure determination of two sugar amino acids via corresponding hydantoin derivatives.
Carbohydr. Res. 2000, 328, 115-126.
Koó¹ M.
An alternative route to 2-deoxysugar and 2,3-unsaturated sugar derivatives via corresponding 1-nitro-1-alkenes.
Tetrahedron Lett. 2000, 41, 5403-5406.
Koó¹ M., Steiner B., Mièová J., Langer V., Ïurík M., Gyepesová D., Smrèok ¥.
Crystal Structure of Methyl 4-amino-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-α-L-talopyranoside.
Molecules 2000, 5, 1113-1120.
Koó¹ M., Steiner B., Mièová J., Langer V., Ïurík M., Gyepesová D.
Synthesis and structure determination of some sugar amino acids related to alanine and 6-deoxymannojirimycin.
Carbohydr. Res. 2001, 332, 351-361.
Mièová J., Steiner B., Koó¹ M., Langer V., Gyepesová D., Ïurík M., Smrèok ¥.
Some amino sugars structurally related to 6-deoxymannojirimycin precursors prepared from methyl 6-deoxy-2,3-O-isopropylidene-α-D-lyxo-hexofuranosid-5-ulose and methyl 2,3-O-isopropylidene-α-D-lyxo- pentodialdo-1,4-furanoside.
Carbohydr. Res. 2002, 337, 663-672.
Mièová J., Steiner B., Koó¹ M., Gajdo¹ J., Langer V., Gyepesová D.
Synthesis, Crystal Structure, and Conformation of Methyl 5-O-acetyl-5-cyano-6-deoxy- 2,3-O-isopropylidene-ß-L-gulofuranoside.
Molecules 2002, 7, 437-446.
Koó¹ M., Mièová J., Steiner B., Alföldi J.
An efficient and versatile synthesis of apiose and some C-1-aldehyde- and/or 2,3-O-protected derivatives.
Tetrahedron Lett. 2002, 43, 5405-5406.
Mièová J., Steiner B., Koó¹ M., Langer V., Gyepesová D.
Synthesis of 4-Carbamoyl-2-oxazolidinones C-4-Linked with a Saccharide Moiety via Bucherer-Bergs Reaction of Hexofuranos-5-uloses.
Synlett 2002, 1715-1717.
Steiner B., Mièová J., Koó¹ M., Langer V., Gyepesová D.
Some non-anomerically C-C-linked carbohydrate amino acids related to leucine - synthesis and structure determination.
Carbohydr. Res. 2003, 338, 1349-1357.
Mièová J., Steiner B., Koó¹ M., Langer V., Gyepesová D.
Characterisation and X-ray crystallography of products from the Bucherer-Bergs reaction of methyl 2,3-O-isopropylidene-α-D-lyxo-pentodialdo-1,4-furanoside.
Carbohydr. Res. 2003, 338, 1917-1924.
Mièová J., Steiner B., Koó¹ M., Langer V., Gyepesová D.
Synthesis and structure determination of some nonanomerically C-C-linked serine glycoconjugates structurally related to mannojirimycin.
Carbohydr. Res. 2004, 339, 2187-2195.
Hirsch J., Langer V., Koó¹ M.
Synthesis and Molecular Structure of Methyl 4-O-methyl-α-D-glucopyranuronate.
Molecules 2005, 10, 251-258.
Langer V., Steiner B., Mièová J., Koó¹ M.
6-O-Cyanomethyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose.
Acta Crystallogr., Sect. E 2005, E61, o779-o781.
Hirsch J., Koó¹ M.
Simple Synthesis of Methyl 2-O-ß-D-Xylopyranosyl-α-L-arabinofuranoside, a Fragment of Natural Arabinoglucuronoxylans.
Chem. Papers 2005, 59, 21-24.
Langer V., Mièová J., Steiner B., Koó¹ M.
3-O-Benzoyl-1,2-O-isopropylidene-ß-D-fructopyranose.
Acta Crystallogr., Sect. E 2005, E61, o2172-o2174.
Langer V., Koó¹ M., Gyepesová D., Sládkovièová M., Lustoò J., Kronek J.
Three isomeric forms of hydroxyphenyl-2-oxazoline: 2-(2-hydroxyphenyl)-2-oxazoline, 2-(3-hydroxyphenyl)- 2-oxazoline and 2-(4-hydroxyphenyl)-2-oxazoline.
Acta Crystallogr., Sect. C 2005, C61, o602-o606.
Mlèochová P., Bystrický S., Steiner B., Machová E., Koó¹ M., Velebný V., Krèmáø M.
Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives.
Biopolymers 2006, 81, 74-79.
Langer V., Gyepesová D., Scholzová E., Lustoò J., Kronek J., Koó¹ M.
2-(4-Hydroxyphenyl)-4,4-dimethyl-2-oxazoline: X-ray and DFT study.
Acta Crystallogr., Sect. C 2006, C62, o416-o418.
Langer V., Mièová J., Steiner B., Koó¹ M.
2-(Benzimidazol-2-ylsulfanyl)butanoic acid.
Acta Crystallogr., Sect. E 2006, E62, o2138-o2140.
Smrèok ¥., Sládkovièová M., Langer V., Wilson C.C., Koó¹ M.
On hydrogen bonding in 1,6-anhydro-ß-D-glucopyranose (levoglucosan): X-ray and neutron diffraction and DFT study.
Acta Crystallogr., Sect. B 2006, B62, 912-918.
Langer V.; Scholtzová E.; Koó¹ M.
1-Phenyl-3-(4-bromophenyl)-5-(4-dimethylaminophenyl)-2-pyrazoline: X-ray and DFT studies.
Acta Crystallogr., Sect. C 2007, C63, o340-o342.
Mlèochová P.; Hájková V.; Steiner B.; Bystrický S.; Koó¹ M.; Medová M.; Velebný V.
Preparation and characterization of biodegradable alkylether derivatives of hyaluronan.
Carbohydr. Polym. 2007, 69, 344-352.
Hýro¹ová E.; Fi¹era ¥.; Jame R.M.-A.; Prónayová N.; Medvecký M.; Koó¹ M.
Diastereoselective synthesis of some carbocyclic 2'-oxa-3'-aza-nucleosides.
Chemistry of Heterocyclic Compounds 2007, 43, 10-17.
Kolaroviè A.; Fi¹era ¥.; Toma ©.; Prónayová N.; Koó¹ M.
1,3-Dipolar cycloaddition of nitrones with alkenes in ionic liquids.
Polish J. Chem. 2007, 81, 1963-1970.
Rehák J.; Fi¹era ¥.; Ko¾í¹ek J.; Pera¹ínová L.; Steiner B.; Koó¹ M.
Samarium diiodide-induced reductive coupling of chiral nitrones with methyl acrylate.
ARKIVOC 2008, part (viii), 18-27.
Hýro¹ová E.; Fi¹era ¥.; Medvecký M.; Reissig H.-U.; Al-Harrasi A.; Koó¹ M.
From sugars to modified nucleosides.
ARKIVOC 2009, part (ix), 122-142.
Langer V.; Steiner B.; Koó¹ M.
2,3:4,6-Di-O-isopropylidene-α-L-sorbofuranose and 2,3-O-isopropylidene-α-L-sorbofuranose.
Acta Crystallogr., Sect. C 2009, C65, o151-o154.
Hirsch J.; Koó¹ M.; Tvaro¹ka I.
Synthesis of saccharide precursors for preparation of potential inhibitors of glycosyltransferases.
Chem. Papers 2009, 63, 329-335.
Steiner B.; Langer V.; Koó¹ M.
Synthesis and X-ray structure of a C5-C4-linked glucofuranose-oxazolidin-2-one.
Carbohydr. Res. 2009, 344, 2079-2082.
Hirsch J.; Koó¹ M.; Kováè P.
Chemical synthesis of oligosaccharides related to plant xylans.
In N.E. Nifantiev (Ed.). Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. Trivandrum: Transworld Research Network, 2009. ISBN 978-81-7895-424-0. Chapter 2.3., p. 61-92.
Institute of Chemistry
Slovak Academy of Sciences
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2017